2015 Fiscal Year Final Research Report
Application of Hydrophobic Micropatterns to Immunosensor with Fluid Control Mechanism for Improving Sensitivity
| Project/Area Number |
25350517
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shinshu University (2015)
Iwate University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 計測工学 / 生物・生体工学 / 分子認識 / 流体工学 / ストレス |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the effectiveness of periodic structure applied to this type of fluid control mechanism to improve the sensitivity of biosensors. We evaluated the functionality of centrifugal fluid valve with micrometer sized periodic structure in the micro-flow channel. A disposable compact disc-based chip with centrifugal fluid valve was designed for this evaluation. In this case, parallel pillars showed higher hydrophobicity than cross-shaped pillars. The transferred volume ratio increased by 20% compared to that without a micro-periodic structure when a protein solution with a similar concentration to that in saliva and plasma was used. It was shown that the static hydrophobicity dominates the switching characteristics in the proposed centrifugal fluid valve. Our study suggests that applying periodic structure to fluid control mechanisms is an effective means of realizing hydrophobic surfaces.
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| Free Research Field |
生体医工学
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