2016 Fiscal Year Final Research Report
Creation of multi-theranostics nanoparticle for multi-strategic therpnosis
| Project/Area Number |
25350530
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Yamaguchi University (2016)
The University of Tokushima (2013-2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 有機シリカ粒子 / セラノスティックス / 光線力学療法 / 磁場温熱療法 / 光線温熱療法 / 診断と治療の一体化 / マルチモーダルイメージング / ナノ医療 |
|---|
| Outline of Final Research Achievements |
We developed novel type of silica nanoparticles, organosilica nanoparticles that are both structurally and functionally different from typical ones and have advantages for multifunctionalization. We have prepared multifunctionalized organosilica nanoparticles for multimodal imaging. In this study we prepared theranostic organosilica nanoparticles enable to combine diagnostics and therapy. We could theranostic organosilica nanoparticles with various pharmacological effects. Multi-theranostic organosilica nanoparticles showed cytotoxic activity on single cell imaging. Improved accumulation of multi-theranostics organosilica nanoparticles in tumor tissue were confirmed using near-infrared in vivo imaging. Furthermore multi-theranostics organosilica nanoparticles revealed therapeutic effects using tumor-bearing mice.
|
| Free Research Field |
ナノ医療
|
