Visualization of in vivo mouse coronary arteries using high intensity quasi-monochromatic x-rays generated by an x-ray mirror

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Japan Synchrotron Radiation Research Institute
• Principal Investigator: Keiji Umetani 公益財団法人高輝度光科学研究センター, 利用研究促進部門, 主幹研究員 (50344396)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マウス冠状動脈撮影 / 血管造影 / 放射光 / Ｘ線ミラー / 準単色Ｘ線 / 心臓疾患診断

Outline of Final Research Achievements

Rat coronary microangiography at the SPring-8 synchrotron radiation facility has been applied to numerous pre-clinical studies by visualization of fine angioarchitectures comparable with those of human angiographic anatomy. Next, we undertook new studies on visualization of mouse coronary arteries because a lot of disease model mice can be produced by gene recombination. We developed a new high-speed imaging system using a combination of high intensity quasi-monochromatic x-rays generated by an x-ray mirror and a sub-millisecond precision x-ray shutter because mouse bodies are smaller than those of rats and mouse heart rates are faster than those of rats. The new system will be an effective tool for pharmacometrics and studies on disease mechanisms using various types of disease model mice.

Free Research Field

医用画像工学