• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Development of nanocarriers for cancer thermochemotherapy

Research Project

  • PDF
Project/Area Number 25350549
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Morimoto Nobuyuki  東北大学, 工学(系)研究科(研究院), 准教授 (00313263)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Makoto  東北大学, 大学院工学研究科, 教授 (60282109)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsナノキャリア / 刺激応答性 / スルホベタインポリマー / 温熱化学療法
Outline of Final Research Achievements

Copolymers of 3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate and poly(ethylene glycol) methacrylate were prepared to develop cancer thermochemotherapy. Among these polymers, the random copolymers formed nanospheres self-assembly in physiological solution conditions. Moreover, the random polymers exhibited little cytotoxicity and effective cellular uptake based on membrane translocation as the main pathway of internalization. The polymer was effectively internalized into cells even after conjugation with doxorubicine, a cancer drug. The conjugated polymer exhibited the cell killing activity without reducing the drug efficacy and induced apoptosis of cancer cells.

Free Research Field

バイオマテリアル

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi