RAFT Miniemulsion Polymerization using Oligosaccharide-Conjugated CTA Producing Antithrombogenic Polymeric Coating Agent

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350550
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Yamagata University
• Principal Investigator: Narumi Atsushi 山形大学, 理工学研究科, 准教授 (60443975)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖鎖修飾CTA / RAFT重合 / ミニエマルション重合 / グリコポリマー / ブロックコポリマー / ポリマー微粒子 / 植物資源高度活用 / 生体適合性

Outline of Final Research Achievements

We have conducted this research to develop polymer coating agents constructing material surfaces showing antithrombogenicity. As a raw material for such polymeric agents, we have focused on the use of end-functionalized vinyl polymers with plant-derived oligosaccharides. A method to prepare end-glycosylated polymers with well-defined structures in water has been developed in this study. Film-formation experiments by casting the solution of the end-glycosylated polymers on the silicone substrate and protein adhesion tests on the film-surface were demonstrated, suggesting that the polymer synthesized in this study has a potential as being applicable to polymeric agents providing material surfaces showing antithrombogenicity.

Free Research Field

高分子化学