Design of polypeptide showing UCST-type phase transition behavior

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350552
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Shimada Naohiko 東京工業大学, 生命理工学研究科, 助教 (10423972)
• Co-Investigator(Renkei-kenkyūsha): Atsushi Maruyama 東京工業大学, 生命理工学研究科, 教授 (40190566)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: UCST / ペプチド

Outline of Final Research Achievements

There are many polymers showing LCST-type phase transition behavior under physiological conditions. However, there is few polymers showing UCST-type phase transition behavior under the conditons. We have reported that poly citrulline polypeptide showed UCST-type behavior. In this study, we estimated effect of optical activity of the polypeptide on UCST-type solution behavior. CD spectra indicated that the polypeptide adopted a-helix conformation and form a bundle structure below phase separation temperature.

Free Research Field

生体高分子化学