2015 Fiscal Year Final Research Report
Development of antibacterial material with reducing cytotoxicity
| Project/Area Number |
25350557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Yoshinao 近畿大学, 生物理工学部, 准教授 (90333509)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ナノ材料 / ハイドロキシアパタイト / 銀 / 抗菌性 |
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| Outline of Final Research Achievements |
Our objective of the project is the development of antibacterial novel nanomaterial with weak cytotoxicity. Synthesis of Ag-doped hydroxyapatite (HAp) nanoparticles with highly dispersibility and crystallinity, examination of coating property, evaluations of material and biological properties were conducted. The highly dispersible Ag-HAp nanoparticles by using the anti-sintering method were prepared. The functionality for nano-coating on polymer substrates was well-satisfied. Antibacterial activities for E. coli. and P. aeruginosa were observed. In cell-adhesion test, human epithelial type 2 cells were well-adhered on the Ag-HAp coating sheet as same as cell culture dish. Thus, the antibacterial Ag-HAp nanoparticles as a coating nanomaterial on medical devices with reducing cytotoxicity have been successively developed.
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| Free Research Field |
医用生体工学・生体材料学
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