2015 Fiscal Year Final Research Report
Preliminary study of urinary L-FABP as early diagnostic biomarker for renal allograft injury.
| Project/Area Number |
25350559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Iwate University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masao 岩手大学, 農学部, 准教授 (20392144)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腎移植 / 虚血再灌流傷害 / L-FABP |
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| Outline of Final Research Achievements |
Expression of the L-typed fatty acid binding protein (L-FABP) was confirmed in feline kidney tissue, especially within renal tubular cells, as well as human. In feline kidney tissue samples, expression of L-FABP was not significantly related to the kidney function.
In kidney ischemia/reperfusion injury and acute kidney rejection models, L-FABP was appeared in tubular cavities before the increase of serum creatinine. L-FABP may play a role as a biomarker for predicting impairment of renal function rather than for expressing kidney damages.
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| Free Research Field |
獣医外科学
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