2016 Fiscal Year Final Research Report
Multi-organ comprehensive aging evaluation and comprehensive management of lifestyle-related diseases
| Project/Area Number |
25350567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 生活習慣病 / 老化 / 臓器障害 / 高血圧 |
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| Outline of Final Research Achievements |
Weinvestigate the association between plasma brain natriuretic peptide (BNP) levels and systolic blood pressure (SBP) variability over a one-year period. Blood pressure was measured in patients treated for hypertension at an outpatient clinic every one to two months over a one-year period. The standard deviation (SD) and the coefficient of variation (CV) were calculated to assess SBP variability. Mean SBP was also calculated over the year. Plasma BNP levels were measured at the end of the one-year period. BNP was found to correlate with mean SBP (r=0.599; P<0.001). However, BNP was not observed to be correlate with either the SD or the CV of the SBP. Multiple regression analysis revealed that only the mean values of SBP were independently associated with BNP (β=0.613; P<0.001). Plasma BNP levels may reflect the average SBP, but not SBP variability over the one-year period prior to the measurement of BNP in patients with hypertension.
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| Free Research Field |
循環器内科
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