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2016 Fiscal Year Final Research Report

Multi-organ comprehensive aging evaluation and comprehensive management of lifestyle-related diseases

Research Project

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Project/Area Number 25350567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionKagawa University

Principal Investigator

MASUGATA HISASHI  香川大学, 医学部附属病院, 教授 (70263910)

Project Period (FY) 2013-04-01 – 2017-03-31
Keywords生活習慣病 / 老化 / 臓器障害 / 高血圧
Outline of Final Research Achievements

Weinvestigate the association between plasma brain natriuretic peptide (BNP) levels and systolic blood pressure (SBP) variability over a one-year period. Blood pressure was measured in patients treated for hypertension at an outpatient clinic every one to two months over a one-year period. The standard deviation (SD) and the coefficient of variation (CV) were calculated to assess SBP variability. Mean SBP was also calculated over the year. Plasma BNP levels were measured at the end of the one-year period. BNP was found to correlate with mean SBP (r=0.599; P<0.001). However, BNP was not observed to be correlate with either the SD or the CV of the SBP. Multiple regression analysis revealed that only the mean values of SBP were independently associated with BNP (β=0.613; P<0.001). Plasma BNP levels may reflect the average SBP, but not SBP variability over the one-year period prior to the measurement of BNP in patients with hypertension.

Free Research Field

循環器内科

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Published: 2018-03-22  

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