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2015 Fiscal Year Final Research Report

Can the joint movement induced mechanical stress reduce pain and restore the joint tissue?

Research Project

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Project/Area Number 25350645
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSuzuka University of Medical Science

Principal Investigator

Asada Keiji  鈴鹿医療科学大学, 保健衛生学部, 准教授 (10440851)

Co-Investigator(Kenkyū-buntansha) TAKAKI Miyako  奈良県立医科大学, 医学部, 研究員 (00033358)
KOIZUMI Munehisa  奈良県立医科大学, 医学部, 研究員 (80382307)
WATANABE Masanori  名古屋学院大学, リハビリテーション学部, 准教授 (60460549)
KITAOKA Hitomi  鈴鹿医療科学大学, 保健衛生学部, 助教 (00410936)
Co-Investigator(Renkei-kenkyūsha) TANAKA Yasuhito  奈良県立医科大学, 医学部, 教授 (30316070)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsメカニカルストレス / 滑膜 / カルシウムイオン / 膝関節
Outline of Final Research Achievements

The first aim of the study was to reveal any interactions of sensory mechanisms to mechanical stimulation (MS) of fibroblast-like synoviocytes (FLS) in co-culture system with dorsal root ganglionic neurons. The results suggested the possibility that the response of FLS to MS included calcium ion release from the intracellular store (endoplasmic reticulum) and calcium ion influx through the TRPV4 channels. MS of synovium may elicit any calcium ion-dependent signal transmissions from FLS to sensory neurons. The second aim of this study was to investigate the histopathological changes in rat knee joint tissue with excessive running. After running of 6 weeks, any changes like osteoarthritis were not observed.The findings indicate that joint movements with ideal weight gives a moderate stress and is beneficial to the joint.

Free Research Field

リハビリテーション科学

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Published: 2017-05-10  

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