The effect of transcutaneous application of CO2 on muscle injury using rat model

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350814
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Kobe University
• Principal Investigator: Sakai Yoshitada 神戸大学, 医学(系)研究科(研究院), 教授 (90397802)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 炭酸ガス経皮吸収 / 筋損傷

Outline of Final Research Achievements

In sports and traumatology medicine, skeletal muscle injuries are common. However, we have not established the most optimal treatment for muscle injuries yet. Recently, we designed a novel transcutaneous CO2 application system using 100% CO2 gas, a transcutaneous CO2 absorption-enhancing hydrogel. In this study, we investigated the effects of transcutaneous CO2 application for injured tibialis anterior muscle in rat.
We investigate histologically injured muscle with or without CO2 absorption. The CO2 group accelerate muscle healing. In addition, from immunostaining and realtime PCR experiments, neo-vascular factor and muscle synthesis factors were also upregulated by CO2 absorption. This study may imply that a transcutaneous CO2 application can bring a therapeutic breakthrough for promotion of injured muscle repair.

Free Research Field

リハビリテーション医学