Elucidation of the signal factors to increase the monocarboxylate transporter expression of skeletal muscle and brain by exercise

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Osaka University of Health and Sport Sciences
• Principal Investigator: Hamada Taku 大阪体育大学, 体育学部, 教授 (00466294)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Tatsuya 京都大学, 大学院人間・環境学研究科, 教授 (00314211)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 運動 / 脳 / 骨格筋 / 乳酸代謝 / モノカルボン酸輸送担体

Outline of Final Research Achievements

This study was to verify the effect of monocarboxylate transporter (MCT) expression in the brain as skeletal muscle and its signal factors to increase MCT expression by exercise. A single bout of exercise increased the neuron-specific MCT2 expression level in the brain. Moreover, MCT1 and MCT4 isoforms were increased. Moreover, the signal factors that increase the brain region specific MCT expression level were examined. The results indicated a possibility that brain lactate production and/or brain-derived neurotrophic factor (BDNF) may become a signal factor that increases the MCT2 expression level in brain. These results suggest that MCT2 expression level of the brain is increased by exercise. As a result of this adaptation phenomenon, lactate uptake ability in the neurons is increased, this can be expected that brain function may enhance.

Free Research Field

運動生理学