Development of a novel nutritional treatment for diabetic retinopathy based on scientific evidence.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kagoshima Prefectural College
• Principal Investigator: ARIMURA EMI 鹿児島県立短期大学, その他部局等, 助教 (40552964)
• Co-Investigator(Kenkyū-buntansha): HORIUCHI MASAHISA 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50264403)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI HIROAKI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (60325777) ; KUCHIWA SATOSHI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90161637)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 栄養指導 / 食事療法 / 糖尿病 / 糖尿病網膜症 / 食事たんぱく質 / 動物モデル / 遺伝子発現 / レプチン受容体

Outline of Final Research Achievements

There have been several reports that diabetic retinopathy is treated by inhibitors of renin-angiotensin system (RAS).We previously showed that low-protein diet suppressed expression of RAS related genes in control mice.Then, we thought the possibility that the low-protein diet was effective for not only the kidney but also the retina. We examined how dietary protein contents affect diabetic retinopathy caused by type 2 diabetes.
As a result, under the same content of energy and fat, dietary protein content affected expression of the genes related to RAS, astrocyte and microglia.Further examination is necessary to explain the pathophysiological meanings of the alterations of the gene expression.

Free Research Field

臨床栄養学