Effects of hyperbaric hyperoxia on bone formation and fracture healing.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Teikyo University (2014-2015); National Center for Geriatrics and Gerontology (2013)
• Principal Investigator: Kawada Shigeo 帝京大学, 医療技術学部, 講師 (20376601)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨折治癒 / 高気圧高酸素 / 骨の石灰化

Outline of Final Research Achievements

The purpose of this study was to investigate whether hyperbaric hyperoxia(HBO) accelerate fracture healing in mice. In this study, we developed an open femur fracture model in mice. In HBO-exposed mice, radiographic, histological and biomechanical findings revealed that HBO conditions accelerate fracture healing. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and plasma calcium concentrations did not change due to the HBO conditions. These results suggest that exposure to HBO enhances bone anabolism and accelerates fracture healing without causing oxidative DNA damage or disruption of plasma calcium homeostasis.

Free Research Field

応用健康科学