Analysis of regulatory mechanism for the maintenance of functionality of reserve cells under nutrition starvation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350882
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokyo
• Principal Investigator: Wagatsuma Akira 東京大学, 情報理工学(系)研究科, 学術支援専門職員 (00347121)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: リザーブ細胞 / 栄養飢餓 / ストレス / 筋萎縮

Outline of Final Research Achievements

Upon serum deprivation, C2C12 culture contains two different subpopulation, multinucleated myotubes and undifferentiated reserve cells, like quiescent satellite cells. Using this cell culture system, we investigated the regulatory mechanism for the maintenance of functionality of reserve cells under nutrition starvation. Reserve cells exhibited more marked tolerance to nutrition starvation than myotubes. Reserve cells did not impair their ability to regulate cell proliferation and differentiation, suggesting the maintenance of their cell functionality.

Free Research Field

運動生化学