2015 Fiscal Year Final Research Report
Role of diet and lifestyles in regulating nonsense mRNA expression and its associated diseases
| Project/Area Number |
25350887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ライフスタイル / ナンセンス型mRNA / 規格外遺伝子 / アウトレット / 予防医学 / ストレス / 高脂肪食 / 運動負荷 |
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| Outline of Final Research Achievements |
Effect of diet and exercise training on nonsense-mediated mRNA decay (NMD) and nonsense mRNA expression was studied in mice. The results show that high cacao butter diet, but not other high fat diet or exercise training, increased nonsense mRNA expression levels in mouse liver. We revealed that the cacao butter-induced increase in nonsense mRNA levels was not dependent on phosphorylation levels of eIF2alpha and expression levels of NMD factor UPF1 and lipogenic protein SCD1.
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| Free Research Field |
代謝栄養学，分子生物学
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