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2014 Fiscal Year Research-status Report

変形性膝関節症の軟骨下骨硬化像の定量化

Research Project

Project/Area Number 25350892
Research InstitutionYokohama City University

Principal Investigator

赤松 泰  横浜市立大学, 医学部, 准教授 (30348114)

Co-Investigator(Kenkyū-buntansha) 小林 秀郎  横浜市立大学, 附属病院, 助教 (10645998)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsknee / osteoarthritis / bone quality / bone density
Outline of Annual Research Achievements

Multi-detector row CTとその3D画像から軟骨下海綿骨の各種パラメータ(bone volume fraction, trabecular thickness, trabecular number, trabecular separation , structure model index, trabecular bone pattern factor, and degree of anisotropy) および2D画像から軟骨下皮質骨幅を測定することが可能である。そこで25年4月より前向きに変形性膝関節症患者の登録を開始し、27年3月までに100例の登録を行った。年齢・身長・体重・肥満度指数・罹患期間など基本情報を記載した。また、DXA法を用い、大腿骨頚部および大腿骨内側顆・外側顆骨密度測定を行った。痛みの強さと膝関節機能は Knee injury and osteoarthritis outcome score, Knee Society knee score and function score で記録した。軟骨下骨骨梁構造は、ラトックシステムエンジニアリング株式会社のTRI/3D-BONソフトウェアーを使い、3D画像から大腿骨顆部軟骨下骨と皮質骨幅の解析を行う。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

25年より変形性膝関節症患者の登録を開始し、27年までに100例の登録を行った。TRI/3D-BONソフトウェアーを使い、3D画像から大腿骨内側顆・外側顆軟骨下骨と皮質骨幅の解析を始めた。

Strategy for Future Research Activity

変形性膝関節症患者100例の大腿骨内側顆・外側顆軟骨下骨と皮質骨幅の解析を終了させ、統計処理を行い、論文の作成する方針である。

Causes of Carryover

解析が遅れたため論文と学会発表が予定通りできなかったため次年度に繰り越しになりました。

Expenditure Plan for Carryover Budget

英語論文作成の英語校正費用と海外国内発表の旅費にしようする計画です。

  • Research Products

    (9 results)

All 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Is the Surgical Epicondylar Axis the Center of Rotation in the Osteoarthritic Knee?2015

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Aratake M, Saito T
    • Journal Title

      The Journal of Arthroplasty

      Volume: 3 Pages: 479–483

    • Peer Reviewed
  • [Journal Article] Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis2014

    • Author(s)
      Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Aratake M, Saito T
    • Journal Title

      Journal of Experimental Orthopaedics

      Volume: 1 Pages: 1-9

    • Peer Reviewed
  • [Journal Article] Arthroscopic suture fixation in patients with a tibial intercondylar eminence fracture using a simple device to penetrate the anterior cruciate ligament2014

    • Author(s)
      Aratake M, Akamatsu Y, Mitsugi N, Taki N, Ota H, Shinohara K, Kobayashi H, Saito T
    • Journal Title

      Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

      Volume: 1 Pages: 67-71

    • Peer Reviewed
  • [Journal Article] The surgical epicondylar axis is a consistent reference of the distal femur in the coronal and axial planes2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Muramatsu S, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 22 Pages: 2947-2953

    • Peer Reviewed
  • [Presentation] Venous thromboembolism after high tibial osteotomy with oral direct factor Xa inhibition2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatubo R, Muramatsu S, Otoshi A, Honda H, Saito T
    • Organizer
      24th Japanese-Korea Combined Orthopaedic Symposium
    • Place of Presentation
      Hakone, Kanagawa
    • Year and Date
      2014-06-06 – 2014-06-06
  • [Presentation] Opening wedge high tibial osteotomy using CT based and image free navigation2014

    • Author(s)
      Akamatsu Y, Kumagai K, Kobayashi H, Kusayama Y, Mitsuhashi S, Saito T
    • Organizer
      24th Japanese-Korea Combined Orthopaedic Symposium
    • Place of Presentation
      Hakone, Kanagawa
    • Year and Date
      2014-06-06 – 2014-06-06
  • [Presentation] Is the surgical epicondylar axis a substitute for the flexion-extension axis?2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
  • [Presentation] Does subchondral sclerosis protect progression of joint space narrowing in patients with varus knee osteoarthritis?2014

    • Author(s)
      Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Mitsugi N, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
  • [Presentation] Changes of the biomarkers in synovial fluid and clinical efficacy of intra-articular injection hyaluronic acid for patients with knee osteoarthritis2014

    • Author(s)
      Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Nakazawa A, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27

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Published: 2016-05-27  

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