2015 Fiscal Year Final Research Report
Study of skeletal muscle regeneration regulatory mechanisms by immunoregulatory receptors.
| Project/Area Number |
25350897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tohoku Gakuin University (2015)
Tohoku Institute of Technology (2013-2014) |
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Principal Investigator |
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| Research Collaborator |
TOBINAI Akiko 東北大学, 加齢医学研究所
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 骨格筋 / 再生制御 / 炎症 / 免疫制御受容体 / シグナル伝達 |
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| Outline of Final Research Achievements |
In this study, we considered the controlling mechanisms through the immunoregulatory receptors of an inflammatory response with skeletal muscle injury and regeneration process using cardiotoxin-induced skeletal muscle injury model. As a result, it was indicated that activation receptor signal molecules regulate the infiltration of F4/80 positive cells into the damaged area in lesion repair and regenerative process of the injured skeletal muscle. In addition, it was show that this activation signal regulates the gene expression of some chemokine receptors in F4/80 positive cells. Moreover, it was indicated that these activation receptor signal molecules also participate in M1/M2 differentiation of F4/80 positive cells. Therefore, a possibility suggested that activating immunoregulatory receptors are involved in the lesion repair and regenerative process of the injured skeletal muscle.
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| Free Research Field |
スポーツ免疫学
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