Macrophage hypothesis for exercise-induced muscle qualitative and quntitative changes-

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokyo (2014-2015); Juntendo University (2013)
• Principal Investigator: IKEDA Shin-ichi 東京大学, 医学(系)研究科(研究院), 助教 (50534898)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マクロファージ / 運動 / インスリン感受性 / インターロイキン６ / GLUT4

Outline of Final Research Achievements

Exercise is powerfull tool for preventing metaobolic syndrome and/or type 2 diabetes in human and rodents. However, the moleular mechanisms are largely unknown. I found that anti-inflamattory macrophages were recruited into skeletal muscle after a single bout of exercise,which regulates insulin sensitivity in skeletal muscle. Resident macrophages produced and secreted chemokines which were major contributor to recruit macrophage into skeletal muscle. Recruited macrophages produced interleukine-6 and it increased GLUT4 expression in sleletal muscle cells. This is underlying mechanism of exercise-induced increase in muscle insulin sensitivity.

Free Research Field

骨格筋生物学