2015 Fiscal Year Final Research Report
The effect of ChREBP activation in the development of metabolic syndrome
| Project/Area Number |
25350911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Noriko 兵庫医科大学, 医学部, 准教授 (10368532)
SUZUKI Keiichiro 兵庫医科大学, 医学部, 教授 (70221322)
EGUCHI Hironobu 兵庫医科大学, 医学部, 講師 (60351798)
YOSHIHARA Daisaku 兵庫医科大学, 医学部, 助教 (00567266)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ChREBP / 酸化ストレス / 糖尿病 / 肥満 |
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| Outline of Final Research Achievements |
Carbohydrate Response Element Binding protein (ChREBP) regulates glucose and lipid metabolism via regulating glycolytic, gluconeogenic, and lipogenic gene expression. The transcriptional activation of ChREBP is regulated by concentration of glucose, however details of the mechanism for this activation remains unclear. In this study, we observed the effect of oxidative stress on the transcriptional activation of ChREBP.
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| Free Research Field |
糖尿病
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