Urinary adiponectin as an early diabetic nephropathy index

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Tokushima Bunri University
• Principal Investigator: Hashida Seiichi 徳島文理大学, 大学共同利用機関等の部局等, 教授 (10156268)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病 / 腎症 / アディポネクチン / バイオマーカー / 免疫測定法 / 尿

Outline of Final Research Achievements

With the aim of using urinary adiponectin (AN) as an index for early diabetic nephropathy, we developed an ultra-sensitive assay for AN. Measurements of blood and urinary concentrations of AN in patients with diabetes, obese subjects without diabetes, and healthy subjects revealed that urinary concentrations of AN did not reflect AN levels in blood, unlike leptin, resistin, or insulin. On the other hand, urinary AN correlated strongly with urinary albumin. Notably, urinary AN levels were high in some subjects in whom microalbuminuria was not detectable. Furthermore, low-molecular-weight AN (trimers) accounted for most AN in the urine, whereas middle- or high-molecular-weight AN predominated in blood. In subjects with low estimated glomerular filtration rate (eGFR), the urinary/blood AN ratio was ten times higher than that of individuals with eGFR within normal range.
In conclusion, urinary AN may offer a useful new index of early diabetic nephropathy.

Free Research Field

臨床化学