Development of Natural Product-like Library by Using Diversity-enhanced Extracts

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350959
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: Tohoku University
• Principal Investigator: Kikuchi Haruhisa 東北大学, 薬学研究科(研究院), 准教授 (90302166)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 天然物化学 / 多様性指向型合成 / 化合物ライブラリー

Outline of Final Research Achievements

Diversity-enhanced extracts are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. The subsequent isolation of each compound produced from such reactions affords a diverse natural product-like library. Although there have been several reports on similar methods that chemically convert natural extracts, diversity-enhanced extracts represents an unprecedented approach in terms of applying reactions to form new carbon-carbon bonds and modify molecular skeletons.
We applied this method of diversification on the medicinal plant, Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, new and diverse sesquitepene-like compounds with some containing new molecular skeletons. Therefore, this method of diversification was efficient for producing chemically-diverse natural products.

Free Research Field

天然物化学