2015 Fiscal Year Final Research Report
Development of a comprehensive synthetic strategy and study of biological activity of yuzurimine alkaloids
| Project/Area Number |
25350960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Okayama University (2014-2015)
University of Tsukuba (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ユズリミン類 / 分子内Wittig反応 / Sm-mediated cyclization / Staudinger反応 / aza-Wittig反応 / 天然物化学 / 全合成 |
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| Outline of Final Research Achievements |
Synthetic study of all the yuzurimine-type alkaloids was investigated. We achieved the construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids by using a unique in situ intramolecular Wittig reaction and samarium-mediated cyclization as key steps. Furthermore, we designed and prepared the tricyclic iminium compound as a common intermediate of heterocyclic portion of all the yuzurimine-type alkaloids, featuring the Staudinger reaction-aza-Wittig reaction.
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| Free Research Field |
天然物合成化学・有機合成化学
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