Searching for bioactive compounds from marine organisms around Sada Cape

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350966
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: Ehime University
• Principal Investigator: kuramoto Makoto 愛媛大学, 学術支援センター, 准教授 (50291505)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 海洋生物 / 生理活性物質 / 共生微生物 / 構造解析

Outline of Final Research Achievements

In Ehime Prefecture, it is a thriving fishing industry, but not worth organisms have been discarded. In the course of our continuing search for biologically active substances from such marine organisms, we isolated bioactive compounds from marine sponges, which was collected at the Sada Cape.
An MS-guided purification of this extract revealed novel bromopyrrole alkaloids and peptide. The planar structures of these compounds ere clarified on the basis of NMR spectroscopic and mass spectrometric data. The stereochemistry of those compounds were suggested by NOE and CD experiments. Such chemicals are considered symbiotic microorganisms have produced. Therefore, separation and identification of symbiotic-microorganisms from marine sponge have been done. Further cultivation of symbiotic microorganisms are under way in our laboratory.

Free Research Field

天然物有機化学