2015 Fiscal Year Final Research Report
Quantal analysis of changes in axonal conduction along myelinated fibers
| Project/Area Number |
25350986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Research Collaborator |
KANEKO KENYA 山形大学, 医学部, 技術専門職員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | オリゴデンドロサイト / 海馬 / 活動電位 / 髄鞘 |
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| Outline of Final Research Achievements |
We established an experimental method for accurate evaluation of axonal conduction of action potentials along myelinated fibers in rat hippocampus by employing quantal-like analysis. For the methods, we measured the latency differences of action potentials and the length of myelin-forming processes which reflects internodal length, and made the histograms for their distribution. This method was useful for detection of the developmental changes of conduction velocity and the modulatory effects of neurotransmitter receptor activation on axonal conduction. These results suggest that this method can be applied for investigation of the interaction between oligodendrocyte/myelin and axon.
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| Free Research Field |
神経生理学
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