Analysis of schizophrenia pathogenesis using mouse models based on human genetics data

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Kyoto University
• Principal Investigator: Sakurai Takeshi 京都大学, 医学(系)研究科(研究院), 准教授 (90615717)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 統合失調症 / マウスモデル / ヒトゲノム解析 / 認知機能 / 社会性行動 / 前頭前野

Outline of Final Research Achievements

We have characterized several behavioral paradigm focusing on cognitive functions which prefrontal cortex is responsible for by using mouse models developed based on the human genetics data of schizophrenia. Moreover, we have also characterized the developmental processes of mouse prefrontal cortex by using gene expression profiles for several different biological processes taken place during development. These results should help us to establish basis for further characterization of mouse models for schizophrenia in order to understand the pathogenesis and pathophysiology of schizophrenia.

Free Research Field

分子神経科学、発達精神障害、トランスレーショナルリサーチ