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2015 Fiscal Year Final Research Report

The analysis of cholinergic modulations of the visual responsiveness

Research Project

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Project/Area Number 25350991
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionNational Center of Neurology and Psychiatry (2015)
The Institute of Physical and Chemical Research (2013-2014)

Principal Investigator

Sohya Kazuhiro  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 室長 (80415207)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords二光子レーザー走査型顕微鏡 / カルシウムイメージング / 大脳皮質視覚野 / 方位選択性 / in vivo / 視覚応答 / 蛍光タンパク質 / 抑制性ニューロン
Outline of Final Research Achievements

In this study, I revealed that the effect of awakening is mediated mainly through the activation of GABAergic neurons, which modifies the visual responses of excitatory neurons. Also I developed the new method of GABAergic neuron activity in 3D space. Then I revealed that GABAergic interneurons form clusters to make their inhibitory function.

Free Research Field

神経生理学

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Published: 2017-05-10  

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