2017 Fiscal Year Final Research Report
Investigation of perceptual and learning characteristics of a genetic disease model animal (Zebrafish)
| Project/Area Number |
25380985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高久 信一 日本大学, 生物資源科学部, 教授 (40102636)
朝比奈 潔 日本大学, 生物資源科学部, 教授 (10147671)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | ゼブラフィッシュ / 遺伝子疾患モデル動物 / オーディオグラム / 光臨界融合周波数 / コントラスト感度 / 学習の可塑性 |
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| Outline of Final Research Achievements |
Zebrafish are becoming popular vertebrate animal models for many biomedical investigations including perceptual and learning research. However, basic behavioral perceptual and learning characteristics, such as behavioral audiogram, behavioral Critical Flicker Fusion Frequency (CFF) and spatial contrast sensitivity function (CSF) have not been determined yet. We have developed equipment for measuring characteristics of zebrafish perception. In addition to the studies of perception, age-dependent change in learning flexibility that can be used as an index of aging of brain function has been examined using a repeated reversal learning paradigm.
Behavioral auditory threshold was lower than physiological data. Behavioral CFF of zebrafish was almost same as that obtained in humans. Spatial CSF obtained in the present experiment was lower than in goldfish. Our learning flexibility experiment revealed that brain flexibility of zebrafish drastically decreased around 420 days post hatch.
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| Free Research Field |
行動分析学
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