2015 Fiscal Year Final Research Report
High-pressure microscopy for controlling the structure of protein filaments
| Project/Area Number |
25390037
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanobioscience
|
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| Research Institution | Kyoto University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 高圧力 / 顕微鏡 / 微小管 / べん毛 / ナノバイオ / 分子モーター / 分子機械 / タンパク質水和 |
|---|
| Outline of Final Research Achievements |
We have developed a high-pressure microscope that enables to observe the structure and function of protein molecules. In this research project, we have studied the conformational changes of protein filaments at high-pressure. By using this system, we were successful to change the helical structure of flagellar filaments and microtubule dynamics.
|
| Free Research Field |
生物物理
|
