Reconsideration of phase retrieval method for coherent X-ray diffraction imaging

2015 Fiscal Year Final Research Report

• Project/Area Number: 25400438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Japan Synchrotron Radiation Research Institute
• Principal Investigator: Joti Yasumasa 公益財団法人高輝度光科学研究センター, XFEL利用研究推進室, 副主幹研究員 (30360415)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: コヒーレント回折イメージング / 位相回復 / X線レーザー / データ解析

Outline of Final Research Achievements

X-ray free electron lasers (XFELs) permit non-crystalline biological samples to be imaged with coherent diffraction imaging (CDI). The iterative computational methods, such as the hybrid input-output (HIO) algorithm, have been proposed to recover the phase information from the diffraction intensity. These methods are often unstable in the presence of noise and missing region in the diffraction pattern. We propose a protocol to reconstruct a reliable image of the sample. Numerical and experimental studies demonstrate the effectiveness of our method.

Free Research Field

計算生物物理学