2016 Fiscal Year Final Research Report
Development of asymmetric cyanation using chiral lithium catalyst
| Project/Area Number |
25410031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Hamamatsu University School of Medicine (2014-2016)
Hokkaido University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 不斉シアノ化 / ルテニウム錯体 / リチウム塩 / アミノ酸配位子 / 光学活性ジホスフィン / ケチミン |
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| Outline of Final Research Achievements |
Asymmetric cyanation of ketimines using lithium cyanide-ruthenium complex catalyst system was studied. Various structured optically active diphosphines and amino acids ligands, solvent, reaction temperature etc. were examined on the cyanation of alpha-Imino esters or alpha-imino lactams. As the results, the substrate was fully consumed using 0.2 mol% of catalyst and the desired products were given in up to 96% ee.
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| Free Research Field |
有機合成化学
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