Development of One-pot Synthesis of Differentially Polysubstituted Benzenes with Various Functional Groups and its Application

2016 Fiscal Year Final Research Report

• Project/Area Number: 25410051
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Osaka Prefecture University
• Principal Investigator: SONODA MOTOHIRO 大阪府立大学, 生命環境科学研究科, 准教授 (90314400)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 多置換ベンゼン / Diels-Alder反応 / 開環芳香族化 / ワンポット合成 / フラン

Outline of Final Research Achievements

One-pot synthesis of differentially polysubstituted benzenes with some functional groups owing heteroatoms was investigated. Diels-Alder reaction of 2-alkylfuran with methyl 3-bromopropiolate and the subsequent ring-opening aromatization of the formed 7-oxanorbornadienes promoted by silica gel or FeCl3 gave 2-bromo-3-hydroxybenzoate derivatives in one-pot. Further functionalization reactions including intramolecular cyclization using the polysubstituted benzenes were also performed.

Free Research Field

化学