2015 Fiscal Year Final Research Report
Activation of Dipoles by Chiral 11 Group Metal Complexes and Diverse Oriented Synthesis
Project/Area Number |
25410053
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Organic chemistry
|
Research Institution | Chuo University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | アゾメチンイリド / 環化付加反応 / 共役付加反応 / キラル配位子 / キラル銀錯体触媒 / アミノ酸 / 多様性合成 / ドラッグディスカバリー |
Outline of Final Research Achievements |
Optically active pyrrolidine derivatives are biologically active compounds and pharmaceutically important. Asymmetric 1,3-dipolar cycloaddition and conjugate addition of glycine iminoesters (azomethine ylide precursors) with active alkenes are effective for divers oriented synthesis of amino acid derivatives. Silver acetate/ThioClickFerrophos complex activates effectively azomethine ylide and catalyzes asymmetric 1,3-dipolar cycloaddition and conjugate addition reaction with active alkenes to afford optically active products with high stereoselection. The methodology can lead to diverse oriented synthesis of optically active amino acids and drug discovery.
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Free Research Field |
有機合成化学
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