2015 Fiscal Year Final Research Report
Development of catalytic transformations that include multiple bond cleavages and formations
| Project/Area Number |
25410054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ロジウム / パラジウム / 金 / 環化 / 炭素－炭素結合切断 / 複素環式化合物 / 多置換ベンゼン / 触媒 |
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| Outline of Final Research Achievements |
In this study, research on catalytic transformations involving multiple bond cleavages and formations was conducted, and more than ten reactions were developed. Spirobiindanones, arylideneindanes, and dihydrophenanthrenes were synthesized by rhodium-catalyzed arylation. Ring-opening coupling reactions of cyclopropenones afforded alkenyl alkynyl ketones and spirocyclic cyclopentanones. Hydrazine derivatives underwent rhodium-catalyzed cyclization reactions to give indoles and phthalazinones. Maleic anhydrides coupled with alkynes and diynes to afford pyrones and benzenes, respectively. Rhodium-catalyzed reaction of pyridylmethylenecyclobutanes gave indanes through a skeletal rearrangement. On the other hand, pyridylmethylenecyclobutenes underwent rhodium-catalyzed intermolecular coupling with alkynes to afford multisubstituted benzenes.
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| Free Research Field |
有機化学
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