Development of novel molecular probes toward bio-imaging and photopharmacology of neural systems

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional solid state chemistry
• Research Institution: Utsunomiya University
• Principal Investigator: OBA Toru 宇都宮大学, 工学(系)研究科(研究院), 教授 (30291793)
• Co-Investigator(Renkei-kenkyūsha): NAKAI Junichi 埼玉大学, 脳抹消科学研究センター, 教授 (80237198) ; OHKURA Masamichi 埼玉大学, 脳抹消科学研究センター, 准教授 (70369172)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 蛍光プローブ / 膜電位 / 神経細胞 / 超分子 / 電子移動 / 環境応答性 / ケミカルバイオロジー

Outline of Final Research Achievements

This study aims at development of novel molecular probes for researches of neural systems. (1) We successfully developed novel voltage sensitive fluorescent probes. (2) We developed selective iodination of the vinyl group and meso-position of a chlorophyll derivative and a natural porphyrin. We also developed facile, green conversion reactions of vinyl group into epoxy, formyl, and acetyl groups via the iodination. (3) We established design principles of pyridyl-pyrrole-based fluorescent probes. (4) We successfully developed novel environment-responsive fluorescent probes.

Free Research Field

生物有機化学