Study of a Potential of Ruthenocenylphosphine as an effective Ligand for Palladium-Catalyzed Cross-Couplibng Reactions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Niigata University
• Principal Investigator: HOSHI TAKASHI 新潟大学, 自然科学系, 助教 (20303175)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: クロカップリング反応 / 鈴木-宮浦反応 / ボリル化反応 / ホスフィン配位子 / パラジウム触媒 / 銅触媒 / 協同触媒

Outline of Final Research Achievements

To take a full advantage of sterically hindered and electron-rich di-tert-butyl(biphenylene-substituted ruthenocenyl)phosphine R-Phos and the dicyclohexyl analogue CyR-phos which we have developed as effective ligands for Pd-catalyzed Suzuki-Miyaura reactions, we studied (1) the development of a series of the sterically and electronically different analogues and the investigation of the correlation between the ligand structure and the catalytic activity, (2) the development of the active bimetallic catalytic system composed with Pd catalyst ligating R-Phos and CuCl for Suzuki-Miyaura reaction of less reactive heheroaryl boranes, (3) the palladium-catalyzed borylation of aryl chlorides and bromides with (BPin)2 using R-Phos and CyR-Phos ligands.

Free Research Field

有機合成化学