Iridium-catalyzed efficient organic synthesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Aoyama Gakuin University
• Principal Investigator: Takeuchi Ryo 青山学院大学, 理工学部, 教授 (00216871)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: イリジウム / 付加環化 / ヒドロアルキル化 / 芳香族複素環化合物 / アルキン / 単純アルケン

Outline of Final Research Achievements

Various transition metal catalysts have been used for organic synthesis. However, a new catalyst is still desired to improve the selectivity and enhance the catalytic activity. Iridium catalyst attracts much attention, because iridium catalyze the useful transformations not achieved by other transition metal catalysts. The aim of this project is to develop atom- and step-economical organic synthesis catalyzed by iridium complex. We studied the reaction scope and reaction mechanism of the following reactions. (1) [2+2+2] cycloaddition of diynes with alkynyl ketones and alkynyl esters. (2) [2+2+2] cycloaddition of diynes with cynamides. (3) [2+2+2] cycloaddition of diynes with acyl cyanides. (4) intermolecular hydroalkylation of simple alkenes with 1,3-diketones and alpha-ketoesters. (5) [2+2+2] cycloaddition of biaryl-linked diynes and heterobiaryl-linked diynes.

Free Research Field

有機金属化学