Development of New Asymmetric Catalysts in Aqueous Solution Based on the Precise Sequence Control of Helical Polymers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Kyoto University
• Principal Investigator: Nagata Yuuya 京都大学, 工学(系)研究科(研究院), 助教 (60512762)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: らせん高分子 / 不斉触媒 / らせん反転 / ポリ（キノキサリン-2,3-ジイル）

Outline of Final Research Achievements

Helical poly(quinoxaline-2,3-diyl)s bearing (S)-1-(alkoxycarbonyl)ethoxymethyl side chains derived from natural L-lactic acid were synthesized to develop new asymmetric catalysts in aqueous solution. In ether solvents, the handedness of the helical chirality of the polymer backbone depends on the length of the alkyl chain in the lactate alkoxy groups. A single-handed copolymer bearing both the pentyl lactate moieties and diphenylphosphino groups also exhibited helix inversion by the choice of ether solvents resulting in the production either R- or S-enantiomers with high enantiomeric excesses in the mixed solvent of ethers and water.

Free Research Field

高分子化学