2015 Fiscal Year Final Research Report
Dual Stimuli-Responsive Self-Assemblies from Elastin-Synthetic Hybrid Graft-Copolymers
| Project/Area Number |
25410132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ペプチド・ポリマーハイブリッド / 多重応答ポリマー / エラスチン類似ペプチド / フォールディング / グラフトポリマー / 下限臨界溶液温度 / 構造色 |
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| Outline of Final Research Achievements |
The main purpose of this research is to fabricate a novel molecular system, in which artificial polymers are conjugated with bio-related peptides as graft chains. An elastin-like peptide (ELP), which is known to take thermo-responsive conformational transition, has been employed as a peptide and attached to the pH-responsive poly(acrylic acid) and poly(allylamine) as graft chains. These conjugates have successfully shown LCST (lower critical solution temperature) behaviors responsive to dual stimuli of pH and temperature. The alternate layer-by-layer assembly prepared from such anionic and cationic conjugates has shown a reversible structural color variation based on thermo-induced polarity change of ELP chains.
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| Free Research Field |
高分子化学
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