A funadamental study on the reaction of boronic acid with saccharide-determination of saccharide with metal complexes having boronic acid moiety-

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Waseda University
• Principal Investigator: Ishihara Koji 早稲田大学, 理工学術院, 教授 (20168248)
• Co-Investigator(Kenkyū-buntansha): ODANI Akira 金沢大学, 薬学系, 教授 (60143913) ; TAKAGI D. Hideo 名古屋大学, 物質科学国際研究センター, 准教授 (70242807) ; INAMO Masahiko 愛知教育大学, 教育学部, 教授 (20176407) ; IWATSUKI Satoshi 甲南大学, 理工学部, 教授 (80373033)
• Co-Investigator(Renkei-kenkyūsha): SUGAYA Tomoaki 早稲田大学, 理工学術院, 助教 (30633367)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ボロン酸 / 糖の定量 / 金属錯体 / 反応機構

Outline of Final Research Achievements

A number of luminescent boronic acid-based sensors for sugars, which utilize a reversible reaction between boronic acid and diol, have been exploited so far. However, a fundamental study on how efficiently progresses the sensing reaction is lacking. In this study, we have performed at first equilibrium and kinetic study on the reactions of some boronic acids with diols in aqueous solution in order to get fundamental information for their reactions, which resulted in proposing an universal reaction mechanism of boronic acid with diol. Then, we have performed similar study on the reactions of boronic acid with sugars to identify the reactive species of boronic acid and a sugar in the sensing reaction, and proposed a comprehensive sensing mechanism. Based on the mechanism, we have designed and synthesized highly luminescent metal complexes with boronic acid moiety, and tried to determine a sugar with monitoring the change in luminescence due to its reactions with these complexes.

Free Research Field

分析化学、溶液化学