2015 Fiscal Year Final Research Report
Development of one step synthesis of glycosyl acceptor substituted by overcrowded silyl group and regioselective glycosidation at 3-OH
| Project/Area Number |
25410170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
HATANO Ken 埼玉大学, 理工学研究科, 准教授 (40332316)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | シリル基 / グリコシル化 / 位置選択的 / 糖鎖合成 |
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| Outline of Final Research Achievements |
Silylation of hydroxyl groups on monosaccharides and lactose were obtained in good yield by one step reaction. In the case of lactose, the silylation occurred on 6, 2' and 6' positions of hydroxyl groups and the trisilylated lactose was able to isolate by recrystallization. Regioselective glycosydation at 3-OH (however 3'-OH in the case of lactose) of the silylated saccharides with a glucose derivative as a glycosyl donor were observed.
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| Free Research Field |
有機ケイ素化学
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