Mechanism of heme transfer and metabolism by pathogenic bacteria

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bio-related chemistry
• Research Institution: Yamaguchi University
• Principal Investigator: Shin-ichi Ozaki 山口大学, 農学部, 教授 (40280581)
• Co-Investigator(Kenkyū-buntansha): Azakami Hiroyuki 山口大学, 農学部, 教授 (40263850) ; Nagano Shingo 鳥取大学, 工学研究科, 教授 (60286440) ; Migita Catharina T 山口大学, 農学部, 教授 (90159161)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヘム / 鉄 / 構造解析 / 機能解析

Outline of Final Research Achievements

Iron is a metal element essential for pathogenic bacteria, but the iron in host cells is tightly bound to proteins such as ferritin or transferrin. Under such circumstances, host heme could be a major source of iron. Some Gram-negative pathogens utilize an extracellular heme-binding protein called hemophore to satisfy their needs for iron. We elucidated heme transport in Pseudomonas aeruginosa, Yersinia pseudotuberculosis, and Eikenella corrodens by spectroscopic and crystallographic methods.

Free Research Field

生物無機化学