2015 Fiscal Year Final Research Report
Evaluations of water-insoluble films made of water-soluble polysaccharides as sustained drug release carriers and cell culture scaffolds
| Project/Area Number |
25410178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 生体材料 / フィルム / 多糖 / ドラッグデリバリーシステム / 細胞 |
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| Outline of Final Research Achievements |
Material properties of free-standing, water-insoluble polysaccharide composite films, made of polyion complexes of anionic polysaccharides such as chondroitin sulfate C (CS) and chitosan (CHI), have been investigated with the focuses on (1) evaluation as sustained drug release carriers, (2) evaluation as cell scaffolds, and (3) development of novel film preparation processes. Regarding (1), results proved that the CS/CHI films possessed abilities to load and to release dye molecules such as methylene blue and proteins such as bovine serum albumin. The release profiles were affected by structure of the drug model and media pH. As for (2), the cultures of fibroblast on the films were succeeded but the cell proliferation was suppressed. Regarding (3), the roll press techniques successfully obtained CS/CHI films having larger sizes. The film showed mechanical anisotropy along the rolling directions, which was not observed for the films obtained using hot press techniques.
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| Free Research Field |
複合化学、生体関連高分子化学、生体機能材料
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