Development of hard tissue adhesive drug delivery system based on phosphorylated pullulan

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410228
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: Okayama University
• Principal Investigator: OKIHARA Takumi 岡山大学, 自然科学研究科, 講師 (70243491)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: プルラン / 多糖 / リン酸化 / 界面活性剤 / 抗菌剤 / ＤＤＳ

Outline of Final Research Achievements

Hard tissue adhesive drug delivery system based on phosphorylated pullulan has developed. Elucidation of the complex formation mechanism and Control of drug release of phosphorylated pullulan and cationic surfactants was reported. Relationship between complex formation and pH, degree of substitution, ionic-strength indicated that neutralization of charge between phosphate group and cation and hydrophobic interaction has important role in complex formation.

Free Research Field

高分子化学