2015 Fiscal Year Final Research Report
Measurement of blood glucose level by using hollow optical-fiber probe based infrared spectroscopy
Project/Area Number |
25420311
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Electron device/Electronic equipment
|
Research Institution | Tohoku University |
Principal Investigator |
KINO SAIKO 東北大学, 医工学研究科, 産学官連携研究員 (30536082)
|
Co-Investigator(Kenkyū-buntansha) |
MATSUURA YUJI 東北大学, 大学院医工学研究科, 教授 (10241530)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 血中グルコース濃度 / 赤外吸収スペクトル / 全反射減衰プリズム / 中空光ファイバ |
Outline of Final Research Achievements |
A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. An analysis of in vivo measurements of human inner lip mucosa revealed clear signatures of glucose in the difference spectra between ones taken during the fasting state and ones taken after ingestion of glucose solutions. A calibration plot based on the absorption peak at 1155 /cm that originates from the pyranose ring structure of glucose gave measurement errors less than 20%.
|
Free Research Field |
赤外分光
|