Bone mechanical functionalization by control of bone quality using stress field

2015 Fiscal Year Final Research Report

• Project/Area Number: 25420755
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Osaka University
• Principal Investigator: Ishimoto Takuya 大阪大学, 工学(系)研究科(研究院), 講師 (50508835)
• Co-Investigator(Renkei-kenkyūsha): NAKANO Takayoshi 大阪大学, 大学院工学研究科, 教授 (30243182)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨配向性 / 骨質 / 応力場 / 人為的応力負荷 / オステオサイト / メカノバイオロジー

Outline of Final Research Achievements

Artificial and quantitative load was applied onto the rat long bone utilizing micro-material testing machine and bone's adaptive responses were analyzed. The preferential orientation of apatite which we focusing on as a bone quality parameter changed depending on the magnitude of the applied load, which represents the success in optimizing the bone mechanical function by applying artificial load through the change of bone quality. In the present study, we achieved substantial results from both clinical (controlling bone mechanical function utilizing an external field) and scientific (clarifying new aspect of bone's adaptive response which had previously only been examined with regard to bone mass) aspects.

Free Research Field

生体材料学