2015 Fiscal Year Final Research Report
Establish of a three-dimensional human peritoneal tissue evaluation method using the cell sheet lamination technology and its application to new treatment development
| Project/Area Number |
25420839
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biofunction/Bioprocess
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | solute permeability / peritoneal tissue / cell sheets / cell sheet lamination / kidney failure |
|---|
| Outline of Final Research Achievements |
This study is one of the development of techniques to assess whether PD liquid used in renal failure treatment is suitable for the living body. By stacking the cell sheet in vitro, it was successful in the production of pseudo-peritoneal tissue composed of three layers. Further, the pseudo-peritoneal tissue lumen structure of a single layer was observed vessels were observed. On the other hand, the solute permeability coefficient of the pseudo-peritoneal tissue, compared to a single-layer structure, 1 / 26.5 in molecular weight of 4000, 1 / 4.5 in molecular weight of 10,000, 1 / 1.9 in molecular weight of 70000, the solute is less likely to pass by organizing It becomes and it is shown that, became a result close to a living body.
To create a pseudo-peritoneal tissue in vitro, it has succeeded in the development of the evaluation method.
|
| Free Research Field |
Tissue engineering
|
