2016 Fiscal Year Final Research Report
Study on Development of Novel Cancer Vaccine Using Hybrid Liposomes
Project/Area Number |
25420842
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biofunction/Bioprocess
|
Research Institution | Sojo University |
Principal Investigator |
GOTO Koichi 崇城大学, 生物生命学部, 教授 (30279377)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | がん / ワクチン / リポソーム / 免疫 |
Outline of Final Research Achievements |
In this study, we examined the induction effects of hybrid liposomes (HL-MUC-1/mB7-1) composed of phospholipids (DMPC) and nonionic surfactants (Tween 80) including synthetic mucin MUC-1 antigen peptides and recombinant mB7-1 membrane proteins on the cancer immunotherapy in vitro and in vivo. CD8+ T cells from the mice intravenously administrated HL-MUC-1/mB7-1 had a tendency to increase the cytotoxicity to the breast cancer cells in vitro, and the prolonged survival was observed in mice implanted with breast cancer cells after the administration of HL-MUC1/mB7-1, suggesting the possibility of novel cancer vaccine using hybrid liposomes.
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Free Research Field |
生体関連化学
|