Inhibitory effects of hybrid liposomes toward cancer metastasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25420843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Sojo University
• Principal Investigator: ICHIHARA Hideaki 崇城大学, 生物生命学部, 准教授 (70369114)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Yoko 崇城大学, 生物生命学部, 教授 (00133562) ; UEOKA Ryuichi 崇城大学, 生物生命学部, 客員研究員 (70099076)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌 / 転移 / シグナル伝達 / ナノメディシン / in vivo

Outline of Final Research Achievements

We examined the therapeutic effects of hybrid liposomes (HL) composed of L-alpha-dimyristylphosphatidylcholine (DMPC) and polyoxyethylene (25) dodecyl ether (C12(EO)25) on the growth of human colorectal cancer (WiDr) cells in vitro and in vivo. The inhibitory effects of HL on the growth of WiDr cells along with apoptosis were obtained in vitro. Remarkable inhibitory effects of HL for the liver metastasis of colorectal cancer cells along with apoptosis were revealed on the basis of histological analysis. Prolonged survival was obtained for the xenograft mouse models of colorectal cancer after the treatment with HL in vivo.

Free Research Field

化学工学