2015 Fiscal Year Final Research Report
Study about the superior colliculus related neural pathway for blindsight by using new genetic method
| Project/Area Number |
25430023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 盲視 / 視床枕 / 上丘 / マカクザル / 遺伝子導入 / サッケード / ウイルスベクター |
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| Outline of Final Research Achievements |
Two blindsight model monkeys, whose primary visual cortex (V1) was removed unilaterally, were used in this study. For the pathway specific blockade of the superior colliculus (SC) to pulvinar pathway, the retrograde vector was injected into the pulvinar and the anterograde vector was injected into the SC. After the vector injections, doxycycline (Dox) was administrated to block the synaptic transmission of the double infected SC neuron, which projected to the pulvinar. The performance of the visually guided saccade task in the affected visual field of V1 lesion was significantly decreased during the Dox administration period than the performance before Dox administration in two monkeys. These results suggest that the SC to pulvinar pathway at least partly mediates the visual information signal for the blindsight.
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| Free Research Field |
神経科学
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